Product Critical Technical Advantages
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Engineering excellence in single-use design features a disposable sensor part that can be swapped in seconds, significantly reducing the risk of cross-contamination and eliminating the need for traditional Cleaning-In-Place (CIP). This is particularly vital for monoclonal antibody (mAb) production where maintaining a sterile environment is paramount.
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Precision engineering with Coriolis technology delivers best-in-class accuracy for mass flow, volume flow, and density in a disposable format. Unlike alternative single-use flow technologies, the Promass U 500 provides multivariable data, allowing operators to monitor concentration and mass balance with the same rigor as traditional stainless steel systems.
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Integration of operational intelligence through Heartbeat Technology automatically recognizes the flow range and verifies the validity of factory calibration immediately upon installation. This eliminates the need for time-consuming field calibrations and ensures that every new disposable sensor is ready for validated production as soon as it is clicked into place.
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Versatile mounting for self-drainability allows the sensor to be installed at various angles to facilitate air bubble escape or total fluid recovery. This flexibility is essential for high-value biopharma batches where every drop of product counts and trapped air can lead to dosing errors or process disruptions.
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Advanced digital integration via Single Pair Ethernet (SPE) and modern communication protocols ensures the Promass U 500 is ready for the digital factory. The transmitter features a built-in web server and WLAN, providing easy access to process data and device health without requiring specialized hardware in the cleanroom.
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One-hand mounting and universal base compatibility allow a single permanent base unit to fit all four disposable line sizes. This provides the highest turndown ratio in the industry and simplifies inventory management for skid builders and facility operators.
Key Device Specifications
| Feature | Specification |
| Technology | Single-Use Coriolis (Disposable flow path) |
| Measuring Variables | Mass flow, density, temperature, volume flow |
| Compliance | cGMP, USP Class VI, animal-origin-free (TSE/BSE) |
| Installation | Single-hand sensor mounting; no field calibration |
| Transmitter | Proline 500 (Remote) with up to 4 I/Os |
| Connectivity | WLAN, Web server, Ethernet/IP, PROFINET |
Field of Application
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Upstream Bioprocessing: Ideal for precise nutrient and media dosing into bioreactors, ensuring optimal cell growth conditions in mAb and vaccine production.
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Downstream Processing: Used in chromatography and filtration steps where accurate mass flow and density measurement are required to optimize yield and product purity.
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Continuous Manufacturing: The preferred choice for modern facilities moving away from batch processing, providing the stable, real-time data needed for long-term automated production runs.
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Buffer Preparation: Ensures highly accurate mixing and dilution of concentrated buffers, a critical step in maintaining consistent pH and conductivity in sterile environments.
